Gastric bypass vastly improves the wellbeing of the sufferers who elect to obtain the surgical procedure. Submit-bariatric hypoglycemia, nonetheless, generally is an extreme complication skilled by 10 to 30 % of sufferers.
Researchers at Joslin Diabetes Center and Harvard John A. Paulson College of Engineering and Utilized Sciences have developed a closed-loop system that mechanically supplies sufferers with an applicable, as-wanted dose of liquid glucagon to deal with this situation. The system, comprised of a steady glucose monitor (CGM) and a glucagon pump that talk through an algorithm-managed software, would enable sufferers to go about their every day’s actions without the concern of dipping into harmful low blood sugar ranges.
Over two hundred thousand individuals in the USA have bariatric surgery annually. Some varieties of these surgical procedures do not solely shrink the dimensions of the abdomen, but in addition, change the way in which meals travel by the intestines. In consequence, excessive ranges of sure hormones are launched from the gut after consuming, and these hormones improve insulin manufacturing. These adjustments, partly, account for the discount in weight problems-related issues, together with kind 2 diabetes. However, in some sufferers, the surgical procedure can set off the physique to over-produce insulin, resulting in sharp drops in blood glucose ranges.
Present therapies for submit-bariatric hypoglycemia embody strictly regulated meal plans, and drugs to scale back insulin manufacturing after meals. As soon as low blood glucose develops, sufferers need to devour sugar. If the affected person has misplaced consciousness, a member of the family might need to administer an emergency dose of glucagon, a drug that will increase glucose. These remedies, nevertheless, are regularly not enough on their very own and will result in unhealthy swings in blood sugar.